|Key Laboratory of Coastal Biology and Bioresource Utilization
1. Introduction of Our Team
The Key Laboratory of Coastal Biology and Bioresource Utilization (KLCBB) at the Yantai Institute of Coastal Zone Research, CAS, is a multidisciplinary research platform in biology and bioresource utilization. It conducts interdisciplinary studies that combine fundamental research and high technology development, including the ecological and physiological studies of coastal plants, animals and microorganisms, the mechanisms of the coastal biological responses and adaptations to the global changes, the utilization of coastal biological and chemical resources, and the conservation and sustainable management of resources of coastal areas.
It houses 11 principle investigators and 28 research-active scientists, and has a good fraction of young and energetic graduate students.
The research in the key lab is mainly supported by the Ministry of Science and Technology, State Oceanic Administration, National Natural Science Foundation of China and CAS.
Following the concept of "create value beyond academic boundaries", The Laboratory of Biological Resources focuses on multidisciplinary research and business needs. At present, Coastal Plant Research Group, High-value Utilization of Biological Resources Research Group, Chemical Ecology and Anti-fouling Research Group, Natural Product Chemistry Group, Coastal Bio-Products R&D Group, Environmental Microbiology Research Group, Microbial Enzyme Research Group. A lot of remarkable achievements have been made in fields of marine resources, marine chemistry, marine anti-fouling technology, chemical ecology, natural products, and marine microorganisms. Our team is supported by many projects and foundation from the national ministries, Chinese Academy of Sciences, Shandong Province and Yantai City, such as the National "Eleventh Five-Year plan" projects, "863" key projects, national Natural Science Foundation, CAS Knowledge Innovation projects, CAS President Special Award funded projects, outstanding Youth Foundation of Shandong Province, Science and Technology Program of Shandong Province, natural Science Foundation of Shandong Province, Science and Technology development projects of Yantai. Two hundred research papers have been published and more 100 publications are indexed by SCI or EI. More than 20 patents have been published, and many of them have been industrialized.
2. Research Field
The Key Laboratory of Coastal Biology and Bioresource Utilization established on the cornerstone of coastal plant resources and coastal microbial resources, set the exploitation and protection of the coastal biological resources as the final target, and oriented with the development of high value-added environmental friendly product. We are going to build the development platform for coastal industrial product, microbial resources, utilization of polysaccharides and chemical ecology by the technology platform of genomics, proteomics and metabolomics.
Coastal Plant Research Group is mainly engaged in coastal plant research, including mining and screening plant functional genomics by genomics and genetic engineering technology, screening and building high-quality germplasm by molecular / genetic engineering, and developing high-value products by metabolic engineering.
High-value Utilization of Biological Resources Research Group is mainly engaged in natural biological active substance screening, targeted modification and corresponding product development, is mainly directed against carbohydrate compounds such as chitosan, chitin, trehalose, inulin for comprehensive utilization development.
Chemical Ecology and Anti-fouling Research Group is mainly engaged in marine ecology and anti-fouling research. The main research fields include: (1) The plant chemical ecology and ecological functions of the plant secondary metabolites; (2) The formation mechanisms and ecological significance of the biofilms in marine fouling; (3) The development of environmental friendly anti-fouling agent; (4) The degradation and alternative development of DDT and other toxic anti-fouling agent.
Natural Product Chemistry Group interests are the discovery of bioactive secondary metabolites from coastal salt-tolerant plants and their symbiotic microbes and nonsymbiotic microbes, and the application of them in agriculture, foods, and drugs, as well as the induced metabolism and biosynthesis of coastal microbes.
Coastal Bio-Products R&D Group focuses on coastal bio-resources, especially salt-tolerant plants and coastal bio-waste, aimed to develop high value-added bio-products, we are committed to research new technologies and processes for sustainable coastal development and utilization of biological resources. At present, we are focused on works as below: breeding of new salt-tolerant plant species; active material extraction, separation and purification from salt-tolerant plants; green bio-processes and development of new functional bio-products.
Environmental Microbiology Research Group is mainly engaged in marine microbiological research: (1) Microbial ecology of the typical coastal environment and important biogeochemical process; (2) Molecular ecology of the coastal eukaryotic microbial; (3) Microbial diversity and coastal resources.
Microbial Enzyme Research Group is mainly engaged in microbial degradation studies of persistent organic pollutants (POPs): (1) Screening of microorganisms digesting of POPs; (2) Functional behavior study of microbial degradation of POPs; (3) Screening pollution and pathogenic microorganisms in the coastal environment, and building a rapid detection method.
Coastal Plant Research Group:
 YD Lu, P Jiang, SF Liu, QH Gan, HL Cui, S Qin. (2010) Methyl jasmonate-or gibberellins A3- induced astaxanthin accumulation is associated with up-regulation of β-carotene ketolase genes (bkts) levels in microalga. Haematococcus pluvialis. Bioresource Technol 101(16): 6468-6474
 YD Lu, XY Chi, ZX Li, QL Yang, SF Liu, QH Gan, S Qin. (2010) Isolation and characterization of a stress-d plastidial Δ12-fatty acid desaturase from the Antarctic microalga Chlorella vulgaris NJ-7. Lipids 45(2): 179-187
High-value Utilization of Biological Resources Research Group:
 Ren Jianming, Liu Jingli, Dong Fang. (2011) Synthesis and hydroxyl radicals scavenging activity of N-(aminoethyl)inulin. CARBOHYDRATE POLYMERS, 85(1): 268-271
 Yang Shaoli, Guo Zhanyong, Miao Fengping. (2010) The hydroxyl radical scavenging activity of chitosan, hyaluronan, starch and their O-carboxymethylated derivatives. CARBOHYDRATE POLYMERS, 82(4): 1043-1045
 Ren Jianming, Liu Jingli, Dong Fang. (2011) Highly efficient synthesis and antioxidant activity of O-(aminoethyl)inulin. CARBOHYDRATE POLYMERS, 83(3): 1240-1244
 Li Rongchun; Guo Zhanyong; Jiang Pingan. (2010) Synthesis, characterization, and antifungal activity of novel quaternary chitosan derivatives. CARBOHYDRATE RESEARCH, 345(13): 1896-1900
 Yang Shaoli, Guo Zhanyong, Zhou Yuling. (2009) Synthesis and moisture absorption and retention activities of a carboxymethyl and a quaternary ammonium derivative of alpha, alpha-trehalose. CARBOHYDRATE RESEARCH, 345(1): 120-123
Chemical Ecology and Anti-fouling Research Group:
 Yang CY, Liu SJ, Zhou SW, Wu HF, Yu JB, Xia CH. Allelochemical ethyl 2-methyl acetoacetate (EMA) induces oxidative damage and antioxidant responses in Phaeodactylum tricornutum. Pesticide Biochem. Physiology, 2011, 100, 93–103.
 Zhou SW, Gu CT, Qian ZY, Xu JG, Xia CH. The activity and selectivity of catalytic peroxide oxidation of chlorophenols over Cu-Al hydrotalcite/clay composite. Journal of Colloid and Interface Science, 2011, 357, 447–452.
 Zhou SW, Qian ZY, Sun T, Xu JG, Xia CH. Catalytic wet peroxide oxidation of phenol over Cu-Ni-Al hydrotalcite. Applied Clay Science, 2011, 53, 627-633..
 Ma XX, Zhou SW, Yang CY, Liu SJ, Bi XL, Xia CH. The influence of triethylamine on the hydrodechlorination reactivity of chlorophenols over Raney Ni catalyst.Catalysis Communications, 2010, 12: 282-285.
 Yang CY, Xia CH, Zhou SW, Liu YD. The permeability effect of microcystin-RR on Escherichia coli and Bacillus subtilis. Chinese Science Bulletin, 2010, 55: 1894-1898.
 Xia CH, Liu Y, Zhou S W, Yang C Y, Liu S J, Xu J, Yu J B, Chen J P, Liang X M. The Pd-catalyzed hydrodechlorination of chlorophenols in aqueous solutions under mild conditions: a promising approach to practical use in wastewater. Journal of Hazardous Materials, 2009, 169, 1029-1033.
 Xia CH, Liu Y, Zhou SW, Yang CY, Liu SJ, Guo SZ, Liu Q, Yu jB, Chen JP. The influence of ion effects on the Pd-catalyzed hydrodechlorination of 4-chlorophenol in aqueous solutions. Catalysis Communications, 2009, 10, 1443-1445.
 Xia CH, Liu Y, Xu J, Yu JB, Qin W, Liang XM. Catalytic hydrodechlorination reactivity of monochlorophenols in aqueous solutions over palladium/carbon catalyst. Catalysis Communications, 2009, 10, 456-458.
 Liu Q, Liu SJ, Zhou SW, Ma XX, Liu XW, Yang CY, Xu JG，Xia CH. Catalytic hydrotreatment of chlorinated benzenes in liquid systems under mild conditions over Pd/C and Raney Ni. Organohalogen compounds, 2009, 71, 2466-2468.
Natural Product Chemistry Group:
 Ming-Feng Qiao, Nai-Yun Ji*, Feng-Ping Miao, Xiu-Li Yin. Steroids and an oxylipin from an algicolous isolate of Aspergillus flavus. Magnetic Resonance in Chemistry, 2011, 49(6), 366–369.
 Xiang-Hong Liu, Xiao-Zhen Tang, Feng-Ping Miao, Nai-Yun Ji*. A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain. Natural Product Communications, 2011, 6(9), 1243–1246.
 Xiao-Dong Li, Feng-Ping Miao, Nai-Yun Ji*. Two new epoxysteroids from Helianthus tuberosus. Molecules, 2011, 16(10), 8646–8653.
 Ming-Feng Qiao, Nai-Yun Ji*, Xiang-Hong Liu, Ke Li, Qing-Mei Zhu, Qin-Zhao Xue. Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. Bioorganic & Medicinal Chemistry Letters, 2010, 20(19), 5677–5680.
 Ming-Feng Qiao, Nai-Yun Ji*, Xiang-Hong Liu, Fang Li, Qin-Zhao Xue. Asporyergosterol, A new steroid from an algicolous isolate of Aspergillus oryzae. Natural Product Communications, 2010, 5(10), 1575–1578.
 Nai-Yun Ji, Xiao-Ming Li, Bin-Gui Wang. Sesquiterpenes and other metabolites from the marine red alga Laurencia composita (Rhodomelaceae). Helvetica Chimica Acta, 2010, 93(11), 2281–2286.
 Nai-Yun Ji*, Wei Wen, Xiao-Ming Li, Qin-Zhao Xue, Hua-Ling Xiao, Bin-Gui Wang. Brominated selinane sesquiterpenes from the marine brown alga Dictyopteris divaricata. Marine Drugs, 2009, 7(3), 355–360.
 Yuan-Yuan Qiao, Nai-Yun Ji*, Wei Wen, Xiu-Li Yin, Qin-Zhao Xue. A new epoxy-cadinane sesquiterpene from the marine brown alga Dictyopteris divaricata. Marine Drugs, 2009, 7(4), 600–604.
 Wei Wen, Fang Li, Nai-Yun Ji*，Xiao-Ming Li, Chuan-Ming Cui, Xiao-Dong Li, Li-Na Zhang, Qin-Zhao Xue, Bin-Gui Wang. A new cadinane sesquiterpene from the marine brown alga Dictyopteris divaricata. Molecules, 2009, 14(6), 2273–2277.
 Nai-Yun Ji*, Xiao-Ming Li, Bin-Gui Wang. Halogenated terpenes and a C15-acetogenin from the marine red alga Laurencia saitoi. Molecules, 2008, 13(11), 2894–2899.
Coastal Bio-Products R&D Group:
 Jun Ning*, Yuetao Yi, Zhe Yao, 2003, An Efficient Method for the Synthesis of 2,6-Branched Galacto-oligosaccharides and itsApplications to the Synthesis of Three tetrasaccharides and a Hexasaccharide Related to the Arabinogalactans. Synlett. 14, 2208-2212.
 Yuetao Yi, Zhongxuan Zhou，Jun Ning, Fanzuo Kong, Jianqiang Li. 2003, Highly Efficient Syntheses of the Phytoalexin-Elicitor Active -(13)-Branched -(16) Heptaglucose and Its Dodecyl Glycoside. Synthesis. 4, 491-496.
 Jun Ning*, Yuetao Yi, F. Kong, 2002, A general strategy for the synthesis of 3,6-branched glucooligosacchrides: facile synthesis of the phytoalexin elicitor oligosaccharides. Tetrahedron lett. 43, 5545-5549.
 Yi Yuetao, Zhao Qianfei, Qian Fengzhen, Ning Jun, 2006, Highly Efficient Regio- and Steroselective Synthesis of -(16)-Branched -(13)-Linked Glucohexaose and Its Analogue, Chinese Journal of Chemistry, 25(3): 385-389.
 Hongyu Zhang, Yuetao Yi, Dawei Feng, Yipeng Wang, Song Qin, 2011, Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine.
 FENG Dawei, LIU Haiyan, LI Fuchao, JIANG Peng, QIN Song,2011, Optimization of dilute acid hydrolysis of Enteromorpha. Chinese Journal of Oceanology and Limnology. 29(6): 1243-1248
Environmental Microbiology Research Group:
 ZHANG Xiaoli, LI Xu, ZHANG Chenggang, LI Xinyu, ZHANG Huiwen. Responses of soil nitrogen-fixing, ammonia-oxidizing, and denitrifying bacterial communities to long term chlorimuron-ethyl stress in the continuously cropped soybean field in Northeast China. Journal of Environmental Sciences (Submitted)
Microbial Enzyme Research Group:
 Xiaoke Hu, Sean Cook, Peng Wang, Huey-min Hwang, Xi Liu, Quinton L. Williams, 2010. In vitro evaluation of cytotoxicity of engineered carbon nanotubes in selected human cell lines. Science of the Total Environment. 408: 1812–1817.
 Jialong Yang, Limei Qiu, Leilei Wang, Mengmeng Huang, Lingling Wang, Huan Zhang, Linsheng Song, 2011. A TRAF and TNF receptor-associated protein (TTRAP) in mollusk with endonuclease activity. Dev Comp Immunol (In press)
The Laboratory of Biological Resources has made remarkable achievements in the fields of marine resources, marine chemistry, marine anti-fouling technology, chemical ecology, natural products, and marine microorganisms. Our team is supported by many projects and foundation form the national ministries, Chinese Academy of Sciences, Shandong Province and Yantai City, such as the National "Eleventh Five-Year plan" projects, "863" key projects, national Natural Science Foundation, CAS Knowledge Innovation projects, CAS President Special Award funded projects, Outstanding Youth Foundation of Shandong Province, Science and Technology Program of Shandong Province, natural Science Foundation of Shandong Province, Science and Technology development projects of Yantai. 200 research papers have been published and more 100 publications are indexed by SCI or EI. More than 20 patents have been published, and many of them have been industrialized.
Table 1 Projects and Foundation directed by our team
Director Project or Foundation Sources Founds(￥) Year
Song Qin Laizhou Bay brackish water and tidal plant resources comprehensive utilization Science and Technology Program of Shandong Province 200,000 2009-2011
Studies of molecular algae Outstanding Youth Foundation of Shandong Province 500,000 2010-2012
Oil-producing micro-algae research Science and Technology development projects of Yantai 500,000 2010-2012
Regulatory pathways and biological basis of the microalgae photosynthetic hydrogen, and the biological survey of the photosynthetic pigment composition CAS Knowledge Innovation projects 120,000 2009-2011
Regulatory pathways and biological basis of the microalgae photosynthetic hydrogen National Natural Science Foundation 140,000 2009-2010
High-quality of the fluorescent products of algae State Oceanic Administration 1,790,000 2009-2010
ZhanyongGuo Coastal biological resources green exploitation utilization technology research Science and Technology Program of Shandong Province 1,000,000 Completed
Amino electropositive on chitosan derivatives antibacterial activity research Sciences special award of CAS President 400,000 Completed
high value utilization of coastal halophytes Program of CAS 1,100,000 Uncompleted
application of trehalose quaternary ammonium salt as moisture absorption humectant The outcome of the key project 800,000 Uncompleted
Plant active substances of chemical modified and high value utilization technology research Sub-project of the national science and technology support project 560,000 Uncompleted
ChuanhaiXia High-value use of biological resources in Wetlands Sub-project of the national science and technology support project 1,300,000 2010-2013
The degradation and alternative development of POPs Sub-project of the national science and technology support project 265,000 2009-2011
Safety evaluation of capsaicin and its anti-pollution features Key projiect of“863” 180,000 2010-2012
Development of brominated indole new anti-fouling agent and anti-fouling paints CAS-region cooperation projects 450,000 2011-2013
Hydrodechlorination-Microbial degradation of PCBs CAS Knowledge Innovation projects 500,000 2011-2013
Effects of Environmental evolution and succession of primary producers on the important biological aquaculture resources CAS Knowledge Innovation projects 300,000 2009-2011
Development of environmental friendly antifouling paints from marine Science and Technology development projects of Yantai 100,000 2011-2013
Development of anti-fouling agent fromMarine algae Science and Technology development projects of Yantai 100,000 2008-2011
Naiyun Ji Study of the silent secondary metabolic pathways of function activation of algae-habitat fungus by epigenetic National Natural Science Foundation 200,000 2012-2014
Separation, identification and mechanism study of the active substance from algae National Natural Science Foundation 250,000 2012-2014
Molecular screening of insecticide function of algae-habitat fungi CAS Knowledge Innovation projects 500,000 2010-2012
Studies of biological activity and chemical taxonomic of algae terpenoid Sciences special award of CAS President 400,000 2009-2011
The effect of Halogenated compounds on the biological activity of two algae sesquiterpene Natural Science Foundation of Shandong provinece 30,000 2010-2012
Study of the structural properties and biological activity of saline compositae sesquiterpene Science and Technology development projects of Yantai 100,000 2010-2011
YuetaoYi Preparation of degrading-enzyme of biological function peptides and marine algae polysaccharide State Oceanic Administration 500,000 2011-2013
Artichoke cultivation in Yellow River Delta saline and processing technology CAS-region cooperation projects 1,000,000 2011-2013
Comprehensive development and utilization of oyster shells CAS-region cooperation projects 450,000 2011-2013
Application development of collagen and polysaccharide product CAS-region cooperation projects 450,000 2011-2013
Strain breeding of high yield 5 - amino levulinic acid Optional project of YIC 200,000 2011-2012
Jun gong Research on function material and the development and utilization in marine environment Optional project of YIC
Study of the environmental microorganisms CAS Hundred Talents
Study of the microbial diversity in Laizhou Bay anaerobic ammonium oxidation process CAS Knowledge Innovation projects
Xiaoke Hu CAS Hundred Talents
Song Qin (Coastal Plant Research Group): Tel 86+0535-2109005，Email firstname.lastname@example.org；
Zhanyong Guo (High-value Utilization of Biological Resources Research Group): Tel 86+0535-2109171，Email email@example.com；
Chuanhai Xia (Chemical Ecology and Anti-fouling Research Group): Tel 86+0535-2109173，Email firstname.lastname@example.org；
Naiyun Ji (Natural Product Chemistry Group): Tel 86+0535-2109176，Email email@example.com；
Yuetao Yi (Coastal Bio-Products R&D Group): Tel 86+0535-2109034，Email firstname.lastname@example.org；
Jun Gong (Environmental Microbiology Research Group): Tel 86+0535-2109123，Email email@example.com；
Xiaoke Hu (Microbial Enzyme Research Group): Tel 86+0535-2109127，Email firstname.lastname@example.org.